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Effects of intracoronary CsA on infarct size and left ventricular remodeling after coronary occlusion in dogs.
The purpose of this study was to determine the effect of cyclosporine A (CsA) on infarct size and left ventricular (LV) remodeling after coronary occlusion. Coronary occlusion for 3 hours resulted in a large MI from ischemia and a small MI from collateral blood flow, ventricular remodeling, and altered gene expression. CsA, given immediately after reperfusion, did not affect infarct size but significantly decreased the frequency of eccentric LV remodeling. In addition, CsA significantly increased baseline mRNA levels for SERCA2a, HSP90, and RyR2 and decreased those for ERK-2, NFkappaB, Dyrk1a, and MRF-4, a known hypertrophic marker. There were no significant changes in levels of other gene markers of LV function and pathological remodeling (alpha-actin, atrial natriuretic peptide, skeletal-actin, beta-actin, aldolase B, caldesmon, transforming growth factor, connective tissue growth factor, and muscle-specific actin). Based on these findings, the authors conclude that the application of CsA after reperfusion decreases the percentage of eccentric remodeling and, therefore, the LV develops a more concentric (systolic) geometry. These findings suggest that CsA administered early during the evolution of an MI provides cardioprotection by attenuating the progression to eccentric remodeling.Q:

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210000. “Parwaaz” was the eleventh single by the Indian duo Junoon. The song was released on 24….
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FM radio in Telugu with FM channels using iRadar APK v2.0 · ParwaazHayJunoonmoviemp4download · 10000000 Best Cool Kids Songs [Top 10] · Carla Bouchillon · family guyEmergency department care of children with common minor head injuries.
The aim of this study is to evaluate the incidence and management of minor head injuries (MHI) among children treated in pediatric emergency departments (PEDs) in Kuwait. A retrospective study was conducted using data from the emergency medical services (EMS) records of all children (aged 1 mo to 14 yr) with MHI who were treated in nine PEDs in Kuwait during a 3-mo period from November 1, 2000, to January 31, 2001. A total of 145 children with MHI were treated during the study period, representing 0.5% of the general hospital population. The incidence of MHI per 100,000 children per month in Kuwait City is significantly lower than that reported in developed countries. The mean and median ages were 5.8 and 5 yr, respectively. One hundred four (72%) children were discharged; 53% from PEDs and 47% from wards. Children with MHI in PEDs had head computed tomography (CT) scan in 43% of the cases and conventional imaging studies in 57% of the cases. Of those with head CT, 41% of the scans were positive, and of those with conventional imaging studies, 32% of the scans were positive. Children with MHI presented with altered mentation in only 24%. In 30% of the cases, there was no significant alteration in the status of consciousness. The median Glasgow Coma Scale (GCS) score of all children (n = 145) was 15, and 72% presented with GCS scores of 15 or greater. Children with MHI in PEDs had significantly higher GCS scores than children with MHI treated in ward (P < 0.001). In 67% of the cases, the treatment was at the discretion of the primary care providers and in 30% of cases there was no treatment. Children with MHI in PEDs in Kuwait City present with a low incidence. Most children with MHI

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