Adler’s Physiology Of The Eye 11th Edition Pdf Free 24 _TOP_
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Adler’s Physiology Of The Eye 11th Edition Pdf Free 24
in chapter 15, paul kaufman, albert alm, leonard a levin, siv f. e. nilsson, james ver hoeve, and samuel wu discuss the physiology of blood-retinal barrier and blood-retinal barrier, which is also referred to as the retinal pigment epithelium/choroid complex and the inner blood-retinal barrier. the authors provide a detailed description of the retinal pigment epithelium (rpe) with an emphasis on its anatomical and physiological features.
in this chapter, dr. kaufman, leonard a levin, siv f. e. nilsson, james ver hoeve, and samuel wu provide a comprehensive discussion of the anatomy of the rpe. these authors discuss various aspects of the anatomy and physiology of the rpe. the authors describe the morphology of the rpe, its histology, and its barrier properties. the authors discuss the synthesis and regulation of the visual chromophores, 11-cis-retinol and 11-cis-retinal, and also the importance of visual pigments in the rpe. the authors also describe the production of retinal pigment epithelium-derived factor, which is a potent chemoattractant for neutrophils. the authors describe the production of retinal pigment epithelium-derived factor, which is a potent chemoattractant for neutrophils.
once a shift in redox homeostasis has occurred, the body is now unable to recover its original state. in such cases, there may be a progressive decline in physiological functions as a result of the loss of the ability to reset the redox balance, which may manifest as a failure of the antioxidative defense system and/or the ability to use ros to regulate signaling pathways. the question may now arise as to whether it is not the toxic side products of the oxidative stress, rather than the free radicals per se, that are the actual danger.
mammalian retinas have been used as a model system for studies of the oxidative stress because of the high concentrations of polyunsaturated fatty acids in these tissues. we therefore chose to study the role of the oxidative stress in the pathophysiology of light-induced retinal damage. this damage occurs in the retina after prolonged illumination with light and is manifested as a marked reduction of the electroretinographic b-wave. in different species the threshold light intensity required to cause retinal damage is strongly reduced by prior exposure to intense light. this phenomenon is called photo-adaptation, and it can be used as an experimental model to study the role of oxidative stress in photoreceptor and inner retinal degeneration.
the exact roles of ros in redox regulation are being elucidated. recent studies have shown that ros function as second messengers in a number of important signaling cascades. these include intracellular pathways that are activated by growth factors, cytokines, and phorbol esters. the activation of these pathways by ros includes the stimulation of cell division, cell migration, and mitogenesis. these effects of ros include the stimulation of map kinase cascades and the activation of the transcription factor ap-1. in addition, the free radicals can activate the mitogen-activated protein kinase cascade, which in turn activates the transcription factor c-fos, thus leading to the formation of ap-1 complexes and the stimulation of gene expression. other ros, including hydrogen peroxide and hydroxyl radicals, also activate transcription factors such as nf-κb. the effect of ros on map kinases and transcription factors may be of particular importance in carcinogenesis and aging. the activation of these signal transduction cascades by ros is also associated with the protection of cells from apoptosis.
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